Despite Peter Frampton having no shortage of songs to close out his farewell shows with -- he's chosen to wrap the night up with a cover of the Beatles' "While My Guitar Gently Weeps." Frampton officially recorded the George Harrison "White Album" favorite on his 2003 collection, Now, and it's been a part of his shows for the better part of two decades. Frampton has been forced to say goodbye to the road upon discovering he's suffering from a degenerative muscle disease called Inclusion-Body Myositus (IBM), that slowly weakens the body's muscles.

Frampton told us he was inspired to record the song after performing it at a benefit concert for 9/11 victims that he organized in December 2001 in Cincinnati soon after Harrison's death: "It was pretty surreal doing it, because you could just feel -- even onstage -- if there hadn't been an audience, we were moving ourselves. Just. . . what had just happened with losing him and everything, and the audience just completely went nuts. It was pretty phenomenal. I mean, they didn't know whether to laugh or cry, y'know? And we felt exactly the same."

In 1970 -- a year before leaving Humble Pie -- Peter Frampton was befriended by George Harrison who asked him to contribute acoustic guitar to assorted tracks for his own mainstream solo debut, All Things Must Pass: "George called me up and he said, 'Look, we need to do some more acoustics,' and this was the best thing ever for me. We just sat, the two of us, in Abbey Road Studios -- the studio they'd done Sgt. Pepper in, and they would just put up another reel. They went through the whole album, basically, and said, 'We need some more acoustics here,' so George and I would just add acoustics (guitar), overdub acoustics, maybe one or two tracks to each track. So basically, I'm playing on just about everything that's not fully electric."

AUDIO: PETER FRAMPTON EXPLAINS HOW HE GOT TO PLAY ON ALMOST ALL OF 'ALL THINGS MUST PASS'
AUDIO: PETER FRAMPTON ON WHILE MY GUITAR GENTLY WEEPS LIVE